Category
Small Molecule CDMOs
Compare small molecule CDMOs for API synthesis, drug product formulation, and finished dosage manufacturing. Filter by chemistry capabilities, scale, and regulatory approvals.
50 companies listed
About Small Molecule Manufacturing
Small molecule manufacturing covers two distinct stages: active pharmaceutical ingredient (API) synthesis and drug product (DP) formulation. API work involves multi-step chemical synthesis, from kilo-lab through pilot-plant to commercial scale. Drug product work transforms the API into tablets, capsules, injectables, or other dosage forms.
Process chemistry is where projects succeed or fail. Look for CDMOs with strong route scouting and process optimization capabilities. A good CDMO can improve yields by 20-40% during scale-up, saving months of development time. Crystallization expertise is particularly critical for controlling polymorphic form and particle size distribution.
How does your CDMO handle potent compounds? Many oncology and hormonal APIs require OEB4 or OEB5 containment. Not every small molecule CDMO has the engineering controls for sub-microgram exposure limits. Verify containment capabilities early -- retrofitting is expensive and slow.
Companies (50)
Axio BioPharma
United States
Axio BioPharma is a pharmaceutical CDMO offering comprehensive services.
Small Molecule APISmall Molecule Drug ProductOral Solid Dose
Osmopharm S.A.
Switzerland
Osmopharm S.A. is a pharmaceutical CDMO offering comprehensive services.
Oral Solid DoseSolid Dose ManufacturingFormulation Development
Avara Pharmaceutical Services
United States
Avara Pharmaceutical Services is a pharmaceutical CDMO offering comprehensive services.
Small Molecule APISmall Molecule Drug ProductOral Solid Dose
7bridges (the7bridges.com)
United Kingdom
7bridges (the7bridges.com) is a pharmaceutical CDMO offering comprehensive services.
Small Molecule APISmall Molecule Drug ProductOral Solid Dose
Matrix Fine Chemical
Switzerland
Matrix Fine Chemical is a pharmaceutical CDMO offering comprehensive services.
Oral Solid DoseSolid Dose ManufacturingFormulation Development
Bend Bioscience
United States
Bend Bioscience is a pharmaceutical CDMO offering comprehensive services.
Oral Solid DoseSolid Dose ManufacturingFormulation Development
Kemwell Biopharma Private Limited
India
Kemwell Biopharma Private Limited is a pharmaceutical CDMO offering comprehensive services.
Small Molecule APISmall Molecule Drug ProductOral Solid Dose
L
Laboratorio Reig Jofre, S.A.
Spain
Laboratorio Reig Jofre, S.A. is a pharmaceutical CDMO offering comprehensive services.
Oral Solid DoseSolid Dose ManufacturingFormulation Development
L
Luina Bio (now AcuraBio)
Australia
Luina Bio (now AcuraBio) is a pharmaceutical CDMO offering comprehensive services.
Oral Solid DoseSolid Dose ManufacturingFormulation Development
Monument Chemical bvba
Belgium
Monument Chemical bvba is a pharmaceutical CDMO offering comprehensive services.
Small Molecule APISmall Molecule Drug ProductOral Solid Dose
J
Juzen Chemical Corp
Japan
Juzen Chemical Corp is a pharmaceutical CDMO offering comprehensive services.
Small Molecule APISmall Molecule Drug ProductOral Solid Dose
Gattefossé S.A.
China
Gattefossé S.A. is a pharmaceutical CDMO offering comprehensive services.
Oral Solid DoseSolid Dose ManufacturingFormulation Development
OPKO HEALTH
Israel
OPKO HEALTH is a pharmaceutical CDMO offering comprehensive services.
Oral Solid DoseSolid Dose ManufacturingFormulation Development
Cohance Lifesciences
India
Cohance Lifesciences is a pharmaceutical CDMO offering comprehensive services.
Small Molecule APISmall Molecule Drug ProductOral Solid Dose
Adelco SA
Greece
Adelco SA is a pharmaceutical CDMO offering comprehensive services.
Oral Solid DoseSolid Dose ManufacturingFormulation Development
BioReliance (Merck KGaA, MilliporeSigma)
Scotland
BioReliance (Merck KGaA, MilliporeSigma) is a pharmaceutical CDMO offering comprehensive services.
Small Molecule APISmall Molecule Drug ProductOral Solid Dose
Bruker Corporation
Switzerland
Bruker Corporation is a pharmaceutical CDMO offering comprehensive services.
Oral Solid DoseSolid Dose ManufacturingFormulation Development
MIDAS CARE PHARMACEUTICAL PVT. LTD.
India
MIDAS CARE PHARMACEUTICAL PVT. LTD. is a pharmaceutical CDMO offering comprehensive services.
Small Molecule APISmall Molecule Drug ProductOral Solid Dose
Hitech Health
Ireland
Hitech Health is a pharmaceutical CDMO offering comprehensive services.
Small Molecule APISmall Molecule Drug ProductOral Solid Dose
Cellab CDMO
Andorra
Cellab CDMO is a pharmaceutical CDMO offering comprehensive services.
Oral Solid DoseSolid Dose ManufacturingFormulation Development
C
China Resources Zizhu Pharmaceutical Co., Ltd.
China
China Resources Zizhu Pharmaceutical Co., Ltd. is a pharmaceutical CDMO offering comprehensive services.
Small Molecule APISmall Molecule Drug ProductOral Solid Dose
M
Mithra Biotechnology Inc
Taiwan
Mithra Biotechnology Inc is a pharmaceutical CDMO offering comprehensive services.
Oral Solid DoseSolid Dose ManufacturingFormulation Development
Bliss GVS Pharma Ltd.
India
Bliss GVS Pharma Ltd. is a pharmaceutical CDMO offering comprehensive services.
Oral Solid DoseSolid Dose ManufacturingFormulation Development
Pell Tech Healthcare Pvt. Ltd.
India
Pell Tech Healthcare Pvt. Ltd. is a pharmaceutical CDMO offering comprehensive services.
Small Molecule APISmall Molecule Drug ProductOral Solid Dose
Tosoh Europe B.V.
Japan
Tosoh Europe B.V. is a pharmaceutical CDMO offering comprehensive services.
Small Molecule APISmall Molecule Drug ProductOral Solid Dose
Bioprox SA (Bioprox Cultures / Bioprox Healthcare)
France
Bioprox SA (Bioprox Cultures / Bioprox Healthcare) is a pharmaceutical CDMO offering comprehensive services.
Oral Solid DoseSolid Dose ManufacturingFormulation Development
TRADICHEM / TRADICHEM Industrial Services
Spain
TRADICHEM / TRADICHEM Industrial Services is a pharmaceutical CDMO offering comprehensive services.
Small Molecule APISmall Molecule Drug ProductOral Solid Dose
Miltenyi Bioindustries (Miltenyi Biotec)
Germany
Miltenyi Bioindustries (Miltenyi Biotec) is a pharmaceutical CDMO offering comprehensive services.
Small Molecule APISmall Molecule Drug ProductOral Solid Dose
UPM Pharmaceuticals
United States
UPM Pharmaceuticals is a pharmaceutical CDMO offering comprehensive services.
Oral Solid DoseSolid Dose ManufacturingFormulation Development
Macrocyclics, Inc.
United States
Macrocyclics, Inc. is a pharmaceutical CDMO offering comprehensive services.
Oral Solid DoseSolid Dose ManufacturingFormulation Development
Kinaxis
Canada
Kinaxis is a pharmaceutical CDMO offering comprehensive services.
Oral Solid DoseSolid Dose ManufacturingFormulation Development
K
Kuehne+Nagel
Switzerland
Kuehne+Nagel is a pharmaceutical CDMO offering comprehensive services.
Small Molecule APISmall Molecule Drug ProductOral Solid Dose
STC Biologics
United States
STC Biologics is a pharmaceutical CDMO offering comprehensive services.
Small Molecule APISmall Molecule Drug ProductOral Solid Dose
B
B+P Logistics GmbH
Germany
B+P Logistics GmbH is a pharmaceutical CDMO offering comprehensive services.
Oral Solid DoseSolid Dose ManufacturingFormulation Development
Lodaat Pharma
United States
Lodaat Pharma is a pharmaceutical CDMO offering comprehensive services.
Oral Solid DoseSolid Dose ManufacturingFormulation Development
Pravesha Industries Private Limited
India
Pravesha Industries Private Limited is a pharmaceutical CDMO offering comprehensive services.
Oral Solid DoseSolid Dose ManufacturingFormulation Development
NextPharma
Finland
NextPharma is a pharmaceutical CDMO offering comprehensive services.
Oral Solid DoseSolid Dose ManufacturingFormulation Development
AEQUILIBRIUM PHARMA S.r.l.
Italy
AEQUILIBRIUM PHARMA S.r.l. is a pharmaceutical CDMO offering comprehensive services.
Oral Solid DoseSolid Dose ManufacturingFormulation Development
Versiti
United States
Versiti is a pharmaceutical CDMO offering comprehensive services.
Small Molecule APISmall Molecule Drug ProductOral Solid Dose
MEGGLE (Business Unit Excipients)
Germany
MEGGLE (Business Unit Excipients) is a pharmaceutical CDMO offering comprehensive services.
Small Molecule APISmall Molecule Drug ProductOral Solid Dose
PeptART Bioscience GmbH
Switzerland
PeptART Bioscience GmbH is a pharmaceutical CDMO offering comprehensive services.
Small Molecule APISmall Molecule Drug ProductOral Solid Dose
Algae Products International Ltd
Qatar
Algae Products International Ltd is a pharmaceutical CDMO offering comprehensive services.
Oral Solid DoseSolid Dose ManufacturingFormulation Development
Evergen (formerly RTI Surgical)
United States
Evergen (formerly RTI Surgical) is a pharmaceutical CDMO offering comprehensive services.
Small Molecule APISmall Molecule Drug ProductOral Solid Dose
Dishman Carbogen Amcis Ltd
China
Dishman Carbogen Amcis Ltd is a pharmaceutical CDMO offering comprehensive services.
Oral Solid DoseSolid Dose ManufacturingFormulation Development
RD‑Biotech
France
RD‑Biotech is a pharmaceutical CDMO offering comprehensive services.
Oral Solid DoseSolid Dose ManufacturingFormulation Development
S
STASON PHARMACEUTICALS, INC.
United States
STASON PHARMACEUTICALS, INC. is a pharmaceutical CDMO offering comprehensive services.
Oral Solid DoseSolid Dose ManufacturingFormulation Development
Chronopost
France
Chronopost is a pharmaceutical CDMO offering comprehensive services.
Oral Solid DoseSolid Dose ManufacturingFormulation Development
P
PacificPharma Corp.
Finland
PacificPharma Corp. is a leading contract development and manufacturing organization headquartered in Finland. We specialize in Cell & Gene Therapy, Fill/Finish, Contract Research Organization (CRO) with state-of-the-art facilities serving clients globally.
Oral Solid DoseSolid Dose ManufacturingFormulation Development
E
ElitePharma LLC
Israel
ElitePharma LLC is a leading contract development and manufacturing organization headquartered in Israel. We specialize in Fill/Finish, Small Molecule API Manufacturer, Formulation Development with state-of-the-art facilities serving clients globally.
Oral Solid DoseSolid Dose ManufacturingFormulation Development
E
EliteTherapeutics B.V.
Italy
EliteTherapeutics B.V. is a leading contract development and manufacturing organization headquartered in Italy. We specialize in Fill/Finish, Clinical Trial Materials, Cell & Gene Therapy with state-of-the-art facilities serving clients globally.
Small Molecule APISmall Molecule Drug ProductOral Solid Dose
Frequently Asked Questions
What is the difference between API and drug product manufacturing?+
API (Active Pharmaceutical Ingredient) manufacturing produces the chemical compound that provides therapeutic effect. Drug product manufacturing takes that API and formulates it into the final dosage form patients receive -- tablets, capsules, injectables, creams, etc. Some CDMOs handle both; many specialize in one.
How do you choose a small molecule CDMO?+
Match your project stage to the CDMO's capabilities. Early-phase needs: strong process chemistry and flexibility. Late-phase needs: validated manufacturing, regulatory filing support, and commercial-scale capacity. Check their experience with your reaction types (hydrogenation, cryogenic, high-pressure) and any special handling requirements (potent, controlled substances).
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